Endocrine Abstracts

The polycystic ovary syndrome (PCOS) is associated with features of the insulin resistance syndrome and altered glucose homeostasis. Factors that play an important role in these processes are still emerging. Pro-inflammatory cytokines may be involved in development of insulin resistance in PCOS. The purpose of this study was to determine if a relationship exists between interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), hepatocyte growth fa...

Osteoprotegerin (OPG) is a potent inhibitor of osteoclastic bone resorption. Besides osteoblasts, OPG is expressed by both endothelial and vascular smooth muscle cells. Moreover, elevated serum OPG has been found in conditions associated with insulin resistance such as obesity, diabetes and/or Cushing syndrome.The aim of the present study was to investigate the relationship between serum OPG and insulin resistance in women with polycystic ovary syndrome ...

Aim: To examine the secretion of insulin and glucagon in PCOS in the context of insulin sensitivity.Patients and methods: 13 healthy women (BMI 21.8(2.2) kg/m2), 21 PCOS without family history of DM2 (FH-); BMI 24.3 (4.4) kg/m2 and 16 PCOS with the 1st degree relative affected by DM2 (FH+); BMI 26.7 (4.2) kg/m2. Euglyceamic hyperinsulinaemic clamp (1mIU kg−1.min−1; with the determination ...